General
Do not drink tap water unless it has been boiled, filtered, or chemically disinfected. Do not drink unbottled beverages or drinks with ice. Do not eat fruits or vegetables unless they have been peeled or cooked. Avoid cooked foods that are no longer piping hot. Cooked foods that have been left at room temperature are particularly hazardous. Avoid unpasteurized milk and any products that might have been made from unpasteurized milk, such as ice cream.

Wear long sleeves, long pants, hats and shoes (rather than sandals). For rural and forested areas, boots are preferable, with pants tucked in, to prevent tick bites.

Don't sleep with the window open unless there is a screen. If sleeping outdoors or in an accomodation that allows entry of mosquitoes, use a bed net, preferably impregnated with insect repellent, with edges tucked in under the mattress. The mesh size should be less than 1.5 mm. If the sleeping area is not otherwise protected, use a mosquito coil, which fills the room with insecticide through the night. In rural or forested areas, perform a thorough tick check at the end of each day with the assistance of a friend or a full-length mirror. Ticks should be removed with tweezers, grasping the tick by the head. Many tick-borne illnesses can be prevented by prompt tick removal.

Do not swim in any lake or river; many are infested with a parasite called bilharzia, which attacks the liver (there are also crocodiles in certain areas). If you're visiting the game parks in Gauteng or Mpumalanga (including Kruger National Park) or the KwaZulu-Natal coast north of Richards Bay, consult your doctor about taking malaria suppressants. AIDS is also a major concern. Take along plenty of sunscreen, insect repellent and a pair of comfortable walking shoes.

Medical and Immunization
Hospital treatment in large cities of South Africa is good but can be expensive.  Medical facilities in rural areas can be basic.  In remote areas, air evacuation is sometimes the only option for medical emergencies. TB, rabies, malaria and cholera are common to South Africa.  Malaria is common to Kruger Park and parts of Mpumalanga, Limpopo province and KwaZulu Natal (particularly the Wetlands area around St Lucia).

There are periodic outbreaks of cholera in the poor communities of rural South Africa, especially in Northern KwaZulu Natal, Mpumalanga, and Limpopo provinces. There has been an outbreak of cholera across the Limpopo region,, flowing from the major outbreak at Beigbridge on the Zimbabwe/South Africa border.  An increase in the number of acute diarrhoea cases have also been reported, including some in other provinces.  Travellers to Limpopo are advised to familiarise themselves with precautions needed to avoid cholera, in particular to drink or use only boiled or bottled water and avoid ice in drinks.  If you suffer from diarrhoea during a visit to South Africa you should seek immediate medical attention.

Measles outbreaks occur from time to time in Kwa Zulu-Natal and Gauteng provinces. A measles outbreak occurred in September 2009, primarily in Gauteng province.